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KMID : 0369820090390060445
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Jorunal of Korean Pharmaceutical Sciences
2009 Volume.39 No. 6 p.445 ~ p.449
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Formulation of mBHT (Modified BoyangHwanoTang) Orally Disintegrating Tablet for Therapeutics of Stroke
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Baek Jong-Suep
Park Yong-Ki
Kim Young-Ho
Kang Jong-Seong
Cho Cheong-Weon
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Abstract
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According to the statistical data, stroke is about 13.9% of leading causes of death. Some herbal medicines including Paeonia lactiflora, Angelica gigas nakai and Prunus persica, etc., had been reported to be effective in preventing stroke and mBHT (Modified BoyangHwanoTang) was an advanced prescription used in Korean clinics. Orally disintegrating tablets (ODT) is useful for patients suffering from dysphagia, motion sickness, repeated emesis and mental disorders. Further, drugs exhibiting satisfactory absorption through the mucosa intended for immediate pharmacological action could be advantageously formulated in ODT. The aim of this study was to develop the most efficient ODT formulation of mBHT. Corresponding herbal medicines comprising mBHT were extracted with water for 3 hr at 95~100oC and then dried. mBHT extract was obtained with about 30% of yield. Subsequently, some pharmaceutical excipients such as spray-dried lactose, crospovidone, glyceryl behenate and/or cogrinded-treated arabia gum were used to achieve an immediate disintegration of mBHT ODT in oral cavity. The requirements of ODT with mechanical strength sufficient to stand the rigors of handling and capability of disintegrating within a few seconds in contact with saliva are indispensable. mBHT ODT prepared by the wet granulation method showed a disintegration time of below 30 sec.
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KEYWORD
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mBHT, Stroke, Orally disintegrating tablet, Disintegration time, Wetting time
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